The Effect of Repeated Influenza Vaccination — Not Always Good

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The immunogenicity of trivalent influenza vaccine is attenuated by the administration of A(H1N1)pdm09 4 months before, an effect partially overcome by the presence of an adjuvant in the former.


Roy-Ghanta S, Van der Most R, Li P, Vaughn DW. Responses to A (H1N1)pdm09 influenza vaccines in participants previously vaccinated with seasonal influenza vaccine: A randomized observer-blind, controlled study. J Infect Dis 2014;210:1419-1430.

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