Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.Aim:
To test baclofen administration for the treatment of persistent hiccup.Method:
We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.Results:
Hiccup stopped in all patients after a single administration of the drug.Conclusions:
Baclofen is a GABAB receptor agonist. It is conceivable that the reduction of dopamine release by GABAB receptor stimulation is able to interrupt hiccup's reflex arc.