Detection of high-risk human papillomaviruses in verrucae of patients with mycosis fungoides and Sézary syndrome: a case series

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Abstract

Background

Mycosis fungoides (MF)/Sézary syndrome (SS) patients are immunocompromised and thus may be susceptible to high-risk human papillomavirus (HPV) infections that are difficult to treat.

Methods

Three patients with verrucous skin lesions, 2 of whom had coexisting squamous cell carcinoma (SCC) near the verruca biopsy site, had biopsies of verruca for histologic examination. HPV typing was performed on fresh verruca biopsies by nested polymerase chain reaction.

Results

A single type of high-risk HPV was identified in each patient's lesion.

Conclusions

HPV may have acted as a cocarcinogen in the development of SCC in two patients and extensive condyloma acuminatum in one.

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