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This study aimed to elucidate the difference in diffusion-weighted magnetic resonance imaging (DWI) and diffusion tensor imaging (DTI) parameters between endometrioid endometrial adenocarcinoma (EEA) and uterine serous adenocarcinoma (SA).Data of patients with pathologically confirmed EEA or SA who underwent DWI and DTI scanning between May 2013 and July 2016 were retrospectively analyzed. Apparent diffusion coefficient (ADC) value from DWI and ADC from DTI (ADCT) map and fractional anisotropy (FA) values from DTI were analyzed and compared statistically. The correlation between ADC and ADCT was analyzed by Pearson correlation analysis. Apparent diffusion coefficient, ADCT, and FA between the 2 groups were compared using independent t test. The effect of ADC, ADCT, and FA in distinguishing EEA and SA was evaluated by receiver operator characteristic curve.Thirty-three patients were enrolled into the study, including 13 cases of SA and 20 cases of EEA. Pearson correlation analysis suggested that the value of ADC was highly related with ADCT in both the SA group (r = 0.812, P = 0.001) and the EEA group (r = 0.858, P < 0.001). The value of ADC and ADCT in the SA group was significantly lower than that in the EEA group; FA was significantly higher than that in the EEA group. Receiver operator characteristic curve analysis showed that ADC and ADCT have high sensitivity and specificity; FA has low sensitivity and high specificity.We suggest that both DWI and DTI could be used in distinguishing EEA from SA. Apparent diffusion coefficient and ADCT possess potential diagnostic value with high sensitivity and specificity.