The aim of this study was to investigate longitudinal relationships between (a) organizational characteristics and work characteristics and (b) organizational characteristics and psychologic work reactions. To get insight into patterns of relationships, self-administered questionnaires were distributed to 596 nurses at time 1 and 379 at time 2. A two-wave full crosslagged structural panel model was used to analyze the data. With regard to the relationships between organizational characteristics and work characteristics, the crosslagged analyses showed stronger support for a pattern of reversed “causation.” Considering relationships between organizational characteristics and psychologic work reactions, no reversed crosslagged relationships were found, although hypothesized cross-sectional relationships were supported. This lack of relationships over time was explained by methodological as well as theoretical arguments.