Pseudolipomatosis in Endometrial Specimens Does Not Represent Uterine Perforation

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Background: Specimens of endometrial biopsies can sometimes present with an artifact within blood, composed of optically clear vacuoles mimicking adipose tissue, pseudolipomatosis. This artifact can be mistaken for adipose tissue and lead to an overdiagnosis of uterine perforation. Case: We describe the case of pseudolipomatosis seen within the evacuated products of conception from a missed abortion. Results: Areas of vacuolization in the blood clot mimicked adipose tissue. However, the vacuoles varied in size and did not contain adipocytes. Conclusion: Familiarity with this artifact will lead to avoidance of overdiagnosis of adipose tissue and uterine perforation in curettage specimens.

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