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Pediatric radiology has faced and passed many challenges over the years. The 33rd Postgraduate Course and 47th Annual Scientific Meeting of the European Society of Paediatric Radiology (ESPR) gave us the opportunity to see the presence of many young and enthusiastic pediatric radiologists. The topics presented during the first 2 days of the postgraduate course were very wide: neuropediatric radiology, chest imaging, and heart and vessels, gastrointestinal and genitourinary radiology, in addition to musculoskeletal and fetal imaging. A large series of scientific sessions were held, particularly focusing on MRI and its use in tissue characterization, prognosis assessment and treatment follow-up of many conditions, both congenital and acquired. Molecular and functional imaging were at the very heart of the symposium lectures.