Can We Reassure Elderly Men with Normal PSA Levels?

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Of 2950 men aged 62 to 91 years with consistent PSA levels of 4.0 ng/mL or less over 7 years, prostate cancer was diagnosed by biopsy in 449 (15.2%). Sixty-seven of these cancers (14.9%) were high-grade tumors (Gleason score of 7 or higher). Normal PSA levels in elderly men should not be cause for reassurance that cancer does not exist. A rise in PSA level at any range should be a cause for concern about cancer.

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