Fractal Analysis of Ibuprofen Effect on Experimental Dog Peri-implantitis

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The aim of this study was to assess the correlation between the fractal analysis of gingival changes and systemic nitro-oxidative stress in a short-term low-dose ibuprofen (IBU) treatment at experimental peri-implantitis (PI).

Materials and Methods:

Six adult male mixed-breed dogs with PI were randomly treated for 2 weeks, 3 with IBU (5 mg/kg b.w.) and 3 with placebo. Clinical and radiological evaluation were performed. Gingival biopsies were assessed by light microscopy, transmission electron microscopy, and fractal analysis. Blood was collected to assay nitric oxide (NOx), total oxidative status (TOS), total antioxidant response (TAR), and oxidative stress index (OSI).


Specific gingival ultrastructural alterations, bone loss, and systemic nitro-oxidative stress were evident in PI-placebo animals. IBU caused significant clinical, microscopic, fractal dimensions (P < 0.01), NOx, TOS, and OSI improvements. IBU caused no important bone and TAR changes.


This study confirms that fractal analysis was a good method to assess the complex morphological changes and correlations with the nitro-oxidative stress in PI. Short-term low-dose IBU treatment consistently improved gingival status and reduced systemic nitro-oxidative stress.

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