Survival Analysis of Implant in Patients With Diabetes Mellitus: A Systematic Review

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To determine the survival trend of dental implants after functional loading for ≥1 year in diabetic patients.

Material and Methods:

An electronic search of the Cochrane Oral Health Group's Trials Register, Medline and Embase, plus a manual search up to December 2015 was performed. Studies assessing the survival rate of dental implants in patients with a diagnosis of diabetes mellitus were considered eligible. Screening of studies, quality assessment, and data extraction were conducted independently by 2 reviewers. Life-table analysis and Kaplan–Meier survival curves were used to evaluate implant survival and to plot the cumulative survival rate and cumulative hazard ratio.


Seven studies, including 1142 implants were identified. The cumulative survival rate was 0.96 ± 0.10 before loading, 0.93 ± 0.10 and 0.91 ± 0.10 at 1 year, and at the end of the follow-up period, respectively. The hazard ratio was 4% during the period of osseointegration, 3% during the first year of loading, and remained constant over the 6-year follow-up.


Patients with diabetes mellitus showed an increasing trend of implant failure during the period of osseointegration and the first year of loading.

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