Bone Regeneration of Macropore Octacalcium Phosphate–Coated Deproteinized Bovine Bone Materials in Sinus Augmentation: A Prospective Pilot Study

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Abstract

Objective:

To investigate the osteogenic potential of macropore octacalcium phosphate (OCP)–coated deproteinized bovine bone materials (DBBMs) in sinus augmentation.

Study design:

Macropore OCP-coated DBBM was manufactured from bovine bone by thermal and chemical processing. Sinus grafts of a lateral window approach with experimental bone were conducted in 10 patients. At 6 months after surgery, a total of 10 specimens were obtained from 10 patients. But, 4 of them were excluded because the amount of specimens was not enough for evaluation. Morphological investigation under scanning electron microscopy and histological evaluation were performed.

Results:

OCP was evenly attached to the surface of the experimental graft and showed a relatively large pore size (300–400 μm) compared with Bio-Oss (100–200 μm). New bone comprised 23.49% (±0.10), and residual graft material comprised 15.39% (±0.06) in bone specimens.

Conclusion:

A macropore-sized design and OCP coating could present a favorable environment for new bone formation in maxillary sinus grafts.

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