Cutaneous γδ T Cells–Selecting a Destination and Asking for Directions in the Thymus

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T cell receptor-defined subsets of γδ T cells differentially localize in cutaneous, intestinal, or reproductive epithelium. In this issue ofImmunity, Xiong et al. show that murine Vγ3+ T cells undergo TCR-dependent selection in the fetal thymus that drives expression of a cutaneous homing receptor.

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