Unraveling the Pros and Cons of Interferon-γ Gene Regulation

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Although transforming growth factor-β (TGF-β) inhibition of interferon-γ (IFN-γ) expression has been known for some time, in this issue of Immunity, Yu et al. (2006) are the first to detail the crosstalk between proinflammatory cytokine and TGF-β signaling that regulates IFN-γ expression.

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