Permission to Proceed: Jak3 and STAT5 Signaling Molecules Give the Green Light for T Helper 1 Cell Differentiation

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Abstract

In this issue of Immunity, Shi et al. (2008) identify a previously unknown requirement in T helper cell differentiation, showing that Jak3 and STAT5 are needed to generate chromatin that is permissive to the activating effects of T-bet.

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