Knocking In the NLRP3 Inflammasome

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Mutations in the human NLRP3 gene cause interleukin-1β-related autoinflammatory syndromes. In this issue of Immunity, Brydges et al. (2009) and Meng et al. (2009) report the characterization of Nlrp3 gene-targeted mice harboring mutations mimicking those causing disease in humans.

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