Tet2: Breaking Down Barriers to T Cell Cytokine Expression

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It has been unclear whether alteration in DNA methylation at cytokine genes during T helper (Th) cell differentiation is a cause or consequence of gene expression. In this issue of Immunity, Ichiyama et al. (2015) show that oxidation of 5-methylcytosine by the methylcytosine dioxygenase Tet2 regulates cytokine production in Th cells.

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