Identity Crisis: CD301b+ Mononuclear Phagocytes Blur the M1-M2 Macrophage Line

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Abstract

Obesity shifts the immune phenotype from M2 macrophage polarization to M1, which causes metabolic dysfunction. In this issue of Immunity, Kumamoto et al. (2016) identify a tissue-resident mononuclear phagocyte population that promotes weight gain and glucose intolerance but are defined by the M2 marker CD301b.

Obesity shifts the immune phenotype from M2 macrophage polarization to M1, which causes metabolic dysfunction. Kumamoto et al. (2016) identify a tissue-resident mononuclear phagocyte population that promotes weight gain and glucose intolerance but are defined by the M2 marker CD301b.

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