Macrophages’ Choice: Take It In or Keep It Out

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In tuberculosis, some macrophages in granulomas assume an epitheloid appearance. Using theMycobacterium marinum-zebrafish model,Cronan et al. (2016)now show that granuloma macrophages undergo reprograming events involving E-cadherin-dependent formation of epithelial-like cell-cell junctions. Interference with the function of E-cadherin in macrophages disorganized the granulomas and protected the fish, introducing new ideas and questions about macrophage function and granulomatous diseases.

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