Amyloid Cascade into Clarity

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In a recent issue ofNature,Sevigny et al. (2016)report findings from a phase 1b clinical trial of aducanumab (a monoclonal antibody targeting misfolded amyloid-β peptides), revitalizing the “amyloid cascade hypothesis” and bringing mononuclear phagocytes center stage in the treatment of Alzheimer’s disease.

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