Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming

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T cell activation and proliferation critical for protective immunity depend on appropriate rewiring of cellular metabolism. In this issue ofImmunity,Mak et al. (2017)show that the antioxidant gluthathione (GSH) controls reactive oxygen species (ROS)-dependent engagement of metabolic signaling pathways that lead to protective T cell responses.

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