Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells

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The identity of PD-1 dependency on other receptors and signaling has been unclear. In a recent issue ofScience,Hui et al. (2017) and Kamphorst et al. (2017)now show that CD28 expression is a target of PD-1-associated phosphatases and is needed for T cell expansion in anti-PD-1 immunotherapy.

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