Innate Immune Cells Speak Manganese

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Abstract

Some metal ions, such as Ca2+ and Zn2+, are involved in intracellular communication in immune cells by acting as second messengers. In this issue ofImmunity, Wang et al. (2018)present findings implying a similar role for an additional metal ion, by showing that manganese participates in the recognition of cytoplasmic DNA.

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