Tissue Crosstalk in T1D: Is Insulin Special?

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Abstract

In a recent issue of Nature,Wan et al. (2018) show that glucose-stimulated β cells secrete insulin B chain peptides relevant to autoimmunity in type 1 diabetes. Peptides such as insulin B:12–20 are released into circulation, where they can be directly and broadly presented by antigen-presenting cells throughout the lymphatic system.

In a recent issue of Nature, Wan et al. (2018) show that glucose-stimulated β cells secrete insulin B chain peptides relevant to autoimmunity in type 1 diabetes. Peptides such as insulin B:12–20 are released into circulation, where they can be directly and broadly presented by antigen-presenting cells throughout the lymphatic system.

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