Natural killer and T cells of innate and adaptive immunity: lymphoid compartments with different requirements for common γ chain-dependent cytokines

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A group of cytokines, including interleukin-2, -4, -7, -9 and -15, are related through the usage of a shared receptor subunit, the common cytokine receptor γ chain, γc. γc-dependent cytokines critically affect the development and maintenance of the lymphoid system. This review will highlight our current knowledge on the γc-dependent cytokine network and on the non-redundant roles that these cytokines play in the development and homeostasis of T and natural killer cells involved in innate and adaptive immunity.

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