Developmental regulation of V(D)J recombination at the TCR α/δ locus

    loading  Checking for direct PDF access through Ovid

Abstract

Summary:

The T-cell receptor (TCR) α/δ locus includes a large number of V, D, J and C gene segments that are used to produce functional TCR δ and TCR α chains expressed by distinct subsets of T lymphocytes. V(D)J recombination events within the locus are regulated as a function of developmental stage and cell lineage during T-lymphocyte differentiation in the thymus. The process of V(D)J recombination is regulated by cis-acting elements that modulate the accessibility of chromosomal substrates to the recombinase. Here we evaluate how the assembly of transcription factor complexes onto enhancers, promoters and other regulatory elements within the TCR α/δ locus imparts developmental control to VDJδ and VJα rearrangement events. Furthermore, we develop the notion that within a complex locus such as the TCR α/δ locus, highly localized and region-specific control is likely to require an interplay between positive regulatory elements and blocking or boundary elements that restrict the influence of the positive elements to defined regions of the locus.

Related Topics

    loading  Loading Related Articles