Inhaled Nitric Oxide in Anesthesia and Critical Care Medicine

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Abstract

Nitric oxide (NO) is a truly unique compound, and although ubiquitous, it has only been used therapeutically since 1991. NO is a free radical, is widely present in many biological systems, and exerts pivotal roles in multiple metabolic and regulatory processes. This chapter focuses on inhaled NO: It describes the physiological basis for the effects of inhaled NO; reviews the literature concerning the medical uses of inhaled NO in the acute care of a variety of adult and pediatric patient populations; discusses the potential adverse effects associated with inhaled NO; and describes delivery and monitoring strategies.

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