Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease

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Abstract

Objective:

To characterize N-terminal pro-brain natriuretic peptide (N-proBNP) and troponin I (TnI) profile following mitral and/or aortic valve surgery and to evaluate correlations with echocardiography measures and outcome criteria.

Design and setting:

Prospective cross-controlled study in a university children's hospital.

Patients:

Twenty children with acquired valvular disease requiring valvular surgery.

Interventions:

We prospectively studied clinical, biochemical, and echocardiographic characteristics at baseline and 6, 12, 24 h and 3–4 weeks postoperatively.

Results:

TnI peaked 6 h after surgery and remained elevated during the first 24 h. N-proBNP was significantly lower 3–4 weeks after surgery than during the perioperative period. Overall, N-proBNP was correlated with the Pediatric Heart Failure Index, left ventricle shortening fraction, left atrium to aorta ratio, left ventricle mass index, end-systolic wall stress, and with outcome measures such as inotropic score, duration of inotropic support, and ICU length of stay. Preoperative N-proBNP was significantly more elevated in patients with complicated outcome than in patients with uneventful postoperative course.

Conclusions:

In pediatric valvular patients, perioperative N-proBNP is a promising risk stratification predicting factor. It is correlated with evolutive echocardiographic measures, need for inotropic support, and ICU length of stay.

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