Low Level Laser Therapy (LLLT) Decreases Pulmonary Microvascular Leakage, Neutrophil Influx and IL-1β Levels in Airway and Lung from Rat Subjected to LPS-Induced Inflammation

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Abstract

Background and Objective

Low level laser therapy (LLLT) is a known anti-inflammatory therapy. Herein we studied the effect of LLLT on lung permeability and the IL-1β level in LPS-induced pulmonary inflammation.

Study Design/Methodology

Rats were divided into 12 groups (n=7 for each group). Lung permeability was measured by quantifying extravasated albumin concentration in lung homogenate, inflammatory cells influx was determined by myeloperoxidase activity, IL-1β in BAL was determined by ELISA and IL-1β mRNA expression in trachea was evaluated by RT-PCR. The rats were irradiated on the skin over the upper bronchus at the site of tracheotomy after LPS.

Results

LLLT attenuated lung permeability. In addition, there was reduced neutrophil influx, myeloperoxidase activity and both IL-1β in BAL and IL-1β mRNA expression in trachea obtained from animals subjected to LPS-induced inflammation.

Conclusion

LLLT reduced the lung permeability by a mechanism in which the IL-1β seems to have an important role.

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