Endogenous Regulation of Inflammatory Pain by T-cell-derived Opioids: When Friend Turns to Foe


    loading  Checking for direct PDF access through Ovid

Abstract

Painful sensation is a hallmark of microbe-induced inflammation. This inflammatory pain is downregulated a few days after infection by opioids locally released by effector T lymphocytes generated in response to microbe-derived antigens. This review focuses on the endogenous regulation of inflammatory pain associated with adaptive T-cell response and puts in perspective the clinical consequences of the opioid-mediated analgesic activity of colitogenic T lymphocytes in inflammatory bowel disease.

    loading  Loading Related Articles