APOE genotype predicts depression in women with Alzheimer's disease: A retrospective study

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SUMMARYObjectiveThe association between the APOE ε4 allele and depression was investigated in a retrospective study of 323 AD patients.MethodsPatients were divided into demographically comparable groups based on the presence or absence of depression.ResultsResults showed that the frequency of APOE ε4 allele was significantly higher in the depressed vs non-depressed AD patients (72% and 58%, respectively), and an interaction revealed that women possessing the APOE ε4 allele were almost four times more likely to be depressed than those without the ε4 allele.ConclusionResults are consistent with recent suggestions that the APOE ε4 genotype may be over-represented among depressed women with AD and highlight the need for additional research investigating the links between APOE genotype, mood, and gender.

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