The prevention of injuries and violence is critical to achieving the Sustainable Development Goals. Every day, in every country – across all income levels – millions of people die or suffer nonfatal injuries from road traffic crashes, burns, drowning, falls, poisonings, or from acts of violence against oneself or others. Much progress has been made in reducing this burden as evidenced by the number of effective and cost-effective solutions to prevent injuries and violence. Developments in the field and the surrounding international policy context over the last decade are also creating new windows of opportunity. These developments include, for example, the Decade of Action for Road Safety; Global and Regional Plans of Action to strengthen the health systems response to prevent violence, especially against women and girls and against children; global reports drawing attention to road safety, interpersonal violence, suicide, drowning, falls, disability, and burn prevention and care; expanded partnerships across sectors; and benchmarks to track progress in meeting the Sustainable Development Goals. The opportunity for countries to step up their efforts and apply what has been learned has never been greater.