The study tried to look deeply inside occupational safety and health legislations for four African countries with focusing on the specific OSH legislation to Micro, Small and Medium enterprises obligated by government to enhance the level of occupational safety and health in those enterprises. How the women are in enterprises landscape in African countries and what areas as OSH professionals can we support one another develop strong OSH integration into these organizations. This is the simple aim of the study. Researchers reviewed existing legislation as this plays a huge role in identifying any gaps that may exist in these countries and begin a discussion to adopt laws to support women workers more. To achieve the aim, we put the scope of the study on MSMEs that have operated or owned by women in garment factories and health units and privet clinical units. The study tools were; collecting the information and go through the legislation for four countries, visitation for sample of enterprises in two sectors, online questionnaires. The conclusion: OSH legislations in all countries are nearby, missing for some safety policies in health sector in some and available in other, OSH legislation cover minimum level of protection in all sectors are in some legislations and need more improvement in other special for SMES. Women protect by laws, they do not allow women to work in dangerous work conditions. Good practice adopting by NGOs and privets sectors with cooperation with the government to enhance the level of OSH in specific sectors like garment in medium and large enterprises. The legislative level can be satisfied. The problem is the low of knowledge, the absence of inspections and training. The owners should adopt the OSH policies in their enterprises with training on fire fighting and evacuation system, enhance the hygiene level.