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Road traffic injury is a global issue, and now all countries are trying to decrease the number of deaths and disabilities, as it is set in the Sustainable Development Goals 3.6. In most of the developing countries, the number of road traffic injury deaths and disabilities are expected to rise, because of motorization, incomplete road safety and immature trauma care system.It has been said that strengthening Post Crash Response, such as developing Emergency Medical Service (EMS) System is one of the key factor to save lives and minimize the disabilities. To achieve better patient outcome by transporting through ambulance, the receiving hospital should have an adequate capacity to provide skills for resuscitation and definitive therapy. In fact, in most of the developing countries, capacity of in-hospital trauma care is immature and forced to cope with the limited resource. This is particularly clear in the least developing countries (LDCs).Nowadays, little is known about the impact of developing EMS system in LDCs. Since 2015, we have been working on the development of EMS in Vientiane Capital, Lao PDR, and conducting a survey to verify the impact of EMS system in Lao PDR. Lao PDR is one of the LDCs, which faces the rapid increase of road traffic injuries and ambulance services are run by the private non-profit sectors. In this presentation, we would like to share the thoughts about how we could develop EMS system in LDCs which would minimize the damage of road traffic accidents.