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Every year, road traffic injuries (RTI) account for over 1.25 million global deaths and more than 50 million injuries. Most of these deaths (90%) occur in low- and middle-income countries (LMICs). Despite such a high burden, LMICs have limited data on road safety and lack effective measures such as safe infrastructure, policies, road safety legislations and enforcement.This panel will focus on lessons learned from over a decade of implementing road safety programs worldwide. This panel will focus on the implementation challenges that have limited global progress on road safety. The speakers will focus on the current status of road safety globally, the need for an integrated approach to road safety, and the application of implementation science principles to improve the efficiency and effectiveness of road safety programs. The speakers on this panel have been involved in implementing different strategies to reduce the burden of RTIs in LMICs, and will use their talks to promote a discussion around innovative approaches to enhance road safety globally. Dr. Adnan Hyder will chair the panel.The current status of Global Road Safety: Dr. Abdulgafoor Bachani will discuss the status of road safety worldwide, highlight various global programs and frameworks, and discuss progress made to-date in the reduction of RTIs.An integrated approach to Road Safety: Dr. Soames Job will discuss the need for an integrated and multi-sectoral approach to road safety. He will highlight examples of success, and lessons that could be applied in LMICs.The implementation challenge: Dr. Nhan Tran will discuss the application of implementation science principles to understand ways in which we could enhance the efficiency and effectiveness of road safety programs globally.This panel will end with a discussion on strategies to improve road safety in LMICs.