Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children

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Abstract

Objective:

Our aim was to investigate the effects of 12-week oral magnesium (Mg) supplementation on the RBC redox system in stable, persistent, moderately asthmatic children (N = 40, 24 boys, 16 girls) aged 4–16 years in a randomized, double-blind, placebo-controlled study.

Design:

Oxidized (GSSG) and reduced (GSH) glutathione, oxyhaemoglobin, methaemoglobin (metHb), hemichrome and bilirubin levels before and after treatment were determined, and GSH stability tests were performed.

Result:

The GSH concentration was significantly higher in the Mg-treated than in the placebo-treated patients after the treatment period. There was a positive correlation between the decreased plasma metHb and hemichrome levels and the decreased plasma haemoglobin concentrations in the Mg-treated patients at the end of the study.

Conclusion:

Mg in the given doses exerts antioxidant activity and influences the glutathione redox system.

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