Stress Ulcer Prophylaxis in the ICU: How Much Is Enough?

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Stress ulcers of the gastrointestinal mucosa have been shown to develop in nearly all types of critically ill patients and endoscopic studies have shown mucosal abnormalities in the majority of patients [1]. As pointed out by Dr Marik in his article in this issue of the Journal of Intensive Care Medicine, the majority of patients do not manifest clinically important bleeding from gastrointestinal stress ulceration [2]. In fact, the incidence of clinically important bleeding from stress ulcers appears to have declined in recent years [3].

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