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The monitoring of increased intracranial pressure in comatose patients has become a standard procedure in many intensive care units. However, the probes currently in use do not always fulfill clinical needs. The search for improved and more cost-effective devices continues. The HanniSet® pressure probe is a microtransducer that is part of an external ventricular drainage system. Under experimental conditions, nine HanniSet® pressure transducers were tested for measurement accuracy. In a prospective study, the HanniSet® system was also examined clinically in intensive care units. Measurement accuracy was investigated in 5 mm Hg steps from 0 to 80 mm Hg. Drift was tested over a period of 10 days at different pressure levels from 0 to 50 mm Hg. The maximum drift was 3 mm Hg at 30 mm Hg. The average drift was less than 0.2 mm Hg/day. The HanniSet® system was used on 43 patients prospectively over a period of 9 months. The infection rate was 4.6%. Experimentally and in the ICU setting, this transducer proved to be reliable, safe, practical, and cost effective.