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Alterations of sodium and glucose concentration may result from disorders of the normal regulatory mechanisms or from excessive intake of glucose, sodium, or free water. In children, hyponatremia most commonly results from excessive free water intake, frequently combined with inadequate sodium intake. The author reports a child who developed hyponatremia and hyperglycemia during cardiopulmonary bypass that was eventually attributed to the large volume of cardioplegia solution that was used. When excess free water administration is suspected as the etiology of hyponatremia, all possible sources should be considered.