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Although cardiogenic shock, whether acute or chronic, most frequently results from depressed left ventricular systolic function, the same syndrome can occur in patients with preserved systolic function. The etiologies and the pathophysiology of the syndrome of cardiogenic shock with preserved ejection fraction are distinctly different from those with reduced ejection fraction. The therapeutic approaches are also different. The prognosis of the patients with acute subset of this syndrome is very favorable, provided prompt diagnosis is made and appropriate treatment is provided. In this review, the important causes, pathophysiology, diagnosis, and therapies of patients with “cardiogenic shock with preserved ejection fraction” are discussed.