A New Immunomodulatory Therapy for Severe Sepsis: Ulinastatin Plus Thymosin α1


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Abstract

ObjectivesTo study the effect of immunomodulatory therapy with ulinastatin plus thymosin α1 on septic patients.MethodA total of 56 sepsis patients were randomized into a treatment group, receiving immuno-modulatory therapy, and a placebo group, a placebo. Acute Physiology and Chronic Health Evaluation II scores, clinical data, lymphocyte subsets, immunological indexes, and coagulation parameters were determined before admission and on the 3rd, 8th, and 28th day after admission to the Intensive Care Unit.ResultsThe treatment group experienced a 78% cumulative survival, the placebo group experienced a 60% cumulative survival; the survival difference was mirrored by Acute Physiology and Chronic Health Evaluation II scores and more quickly improved leukocyte counts, lymphocyte counts, coagulation parameters, and cytokine levels in the treatment.ConclusionsCombined immuno-modulatory therapy with ulinastatin plus thymosin α1 appears to yield improved survival for patients with sepsis; this finding should be verified in larger clinical trials.

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