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The purpose of this study was to identify risk factors associated with inappropriate continuation of neuroleptics postdischarge from the intensive care unit (ICU) and hospital.A retrospective chart review was performed including all patients greater than 18 years of age who received neuroleptic medications in an ICU.One hundred sixty-one patients were included during the 12- month study period. There were 85 (53%) patients discharged from the ICU with inappropriate continuation of a neuroleptic medication. There were 54 (34%) patients discharged from the hospital with inappropriate continuation of a neuroleptic medication. Patients were more likely to be discharged from the ICU with an inappropriate neuroleptic if they were prescribed multiple neuroleptics (P = .02), did not have a urine drug screen collected at admission (P = .023), or if trazodone was utilized in their therapy (P = .004). Patients were more likely to be discharged from the hospital with a neuroleptic if they had multiple neuroleptic orders (P = .0001) or if trazodone was utilized in their therapy (P = .0023).Risk factors associated with the continuation of inappropriate neuroleptic medications upon discharge from the ICU or the hospital include multiple neuroleptic medications prescribed, the lack of a urine drug screen upon admission, and the utilization of trazodone.