XRCC3haplotypes and risk of gliomas in a Chinese population: A hospital-based case-control study

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In mammalian cells, X-ray repair cross-complementing group3 (XRCC3) plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in theXRCC3gene may potentially affect the repair of DSBs and thus confer susceptibility to gliomas. In this study, we used a haplotype-based approach to investigate whether 4 tagging single nucleotide polymorphisms of theXRCC3gene are associated with risk of gliomas in 771 glioma patients and 752 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by the unconditional logistic regression, and haplotype associations were estimated using Haplo.Stat. After adjustment for age and sex, the variant G allele of rs861530 and T allele of rs3212092 were significantly associated with an increased risk of gliomas (AG/GGversusAA: adjusted OR = 1.44, 95% CI = 1.15–1.80,p= 0.001 and CT/TTversusCC: adjusted OR = 1.66, 95% CI = 1.12–2.46,p= 0.013, respectively). Consistent with these results,XRCC3haplotype “GGCC” containing rs861530 G allele and haplotype “AGTC” containing rs3212092 T allele were also significantly associated with an elevated risk of gliomas compared with the common haplotype “AGCC” (adjusted OR = 1.35, 95% CI = 1.14–1.58,p= 0.000 and adjusted OR = 1.67, 95% CI = 1.11–2.52,p= 0.015, respectively). Our results suggest that common genetic variants in theXRCC3gene may modulate glioma risk. © 2009 UICC

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