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Scaling and root planing are the causal procedure in the treatment of periodontitis. Many attempts have been made to improve the outcome. The aim of this study was to verify the influence of the extended use of chlorhexidine after one-stage full-mouth (FM) SRP in patients with chronic periodontitis on the clinical outcome after 3 months.Eighty-one patients with pockets ≥5 mm were treated by FM. All patients rinsed additionally with 0.2% chlorhexidine (CHX) twice daily over 3 months. Plaque index, bleeding on probing, probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and after 1 and 3 months.In the test group, all variables were significantly improved after 1 and 3 months. Mean reduction of PD and CAL gain was 2.25 ± 1.08 and 1.67 ± 1.08 after 1 and 2.99 ± 1.11 and 2.33 ± 1.31 after 3 months respectively.Over 3 months of extended use of CHX mouth rinse after SRP showed slightly but statistically significant better results.