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To evaluate the effect of oral hygiene behaviour, dental anxiety, self assessed dental status and treatment necessity on dental caries status of medical students.The study was conducted among 345 medical students of Udaipur city, India who had provision for free dental services and the study was based on a questionnaire which consisted of two parts, first part containing questions regarding self assessment of dental status and treatment necessity along with oral hygiene behaviour and the later part comprised of Corah Dental Anxiety scale (DAS). Clinical examination was based on the WHO caries diagnostic criteria.Females perceived greater dental anxiety than males. Individuals claiming poor dental status had higher mean decayed, missing and filled teeth (DMFT) score (6.67) than good (2.89) and fair (4.44). The mean decayed component among the anxious students (5.4) was almost twice that of less anxious (2.77) student population. DAS constituted the first major contributor for missing component followed by smoking status which alone explained a variance of 7.1%. The cumulative variance explained by all the independent variables on the DMFT status accounted to 56.4% with self assessed dental status alone contributing a variance of 44.9%. The most significant (P < 0.001) contributor for filled component was self assessed dental status (14.5%).Oral hygiene behaviour, dental anxiety, self assessed dental status and treatment necessity significantly affected the dental caries status of medical students.