Rapid response to infliximab in severe pustular psoriasis, von Zumbusch type


    loading  Checking for direct PDF access through Ovid

Abstract

Tumor necrosis factor-alpha (TNF-α) is a chemokine secreted by T cells which is thought to play a critical role in the pathophysiology of psoriasis. The monoclonal antibody, infliximab, complexes with TNF-α, rendering it inactive. A recent clinical trial has reported the clinical benefit and safety of infliximab in moderate to severe plaque psoriasis. We report a case of rapid response and clinical benefit using infliximab in severe pustular psoriasis of von Zumbusch.

    loading  Loading Related Articles