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Association of malignant melanoma (MM) with various clinical forms of skin depigmentation is well-known. We report a case highlighting the importance of careful examination of patients with skin hypomelanoses, including vitiligo and halo nevi, in order to exclude the presence of MM.A 66-year-old woman presented with a 6-month history of vitiligo-like depigmentation of the face and halo nevi. Physical examination unexpectedly revealed also the presence of a regressing MM associated with a clinically evident lymphoadenopathy. Predominant dermoscopic features of the lesion were an irregular vascular pattern and regression structures, associated with peripheral areas of irregular pigmentation without pigment network.The literature concerning the association between leukoderma and MM is also reviewed.