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To study the influence of clinical variables on health-related quality of life (HRQoL) among women with eating disorder (ED) using beta-binomial regression (BBR) to analyze scores on the ShortForm 36 (SF-36) as dependent variable.Female patients diagnosed with ED completed the SF-36 at the beginning of the study and after 2 years of treatment. Sociodemographic and clinical information was recorded. For the multivariate analysis, we used BBR models to identify factors that influence SF-36.Questionnaires were completed by 193 women at baseline and 158 (82%) after 2 years of treatment. Anxiety, depression, and the severity of ED, explained scores in most domains of the SF-36 at baseline. The main predictor of HRQoL after 2 years of follow-up was the HRQoL in the same domain at baseline. However, depression, anxiety, and duration of symptoms at baseline also significantly influenced HRQoL after 2 years of treatment in some domains. Higher levels of anxiety or depression, longer duration of symptoms, and poorer SF-36 scores at baseline were associated with worse HRQoL after 2 years of treatment and follow-up.BBR models provide understandable results for clinicians and can be used in multivariate models with HRQoL dependent variables.