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A general numerical tool for the analysis of three–dimensional bimaterial interface cracks is presented in this paper. The proposed tool is based on a multidomain formulation of the Boundary Element Method (BEM), with the crack located at the interface of the domain. Mixed mode stress intensity factors are computed along the three-dimensional crack fronts using the Energy Domain Integral (EDI) methodology and decoupled via the Interaction Integral. The capability of the procedure is demonstrated by solving a number of examples. The last of these examples consists in a thick centre cracked panel for which the behaviour of the J-integral and the mixed-mode stress intensity factors along the crack front is studied as a function of the material mismatch.