Endometrial Carcinomas With Lymph Node Involvement: Novel Histopathologic Factors for Predicting Prognosis

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Summary:The purpose of this study was to evaluate the clinicopathologic prognostic factors of endometrial carcinoma with lymph node metastasis (stage IIIc) in 24 patients with endometrial carcinoma. Differences in survival rates were analyzed for each clinicopathologic factor. The ratio of lymph nodes containing metastatic tumor to dissected lymph nodes (metastatic ratio), invasion of tumor cells into perinodal fat, and the presence of desmoplasia were examined. No statistically significant differences in survival rates were observed between any of the histologic parameters of the primary tumors. Cases with a high metastatic ratio exhibited significantly lower survival rates. Cases without tumor invasion into perinodal fat had significantly longer survival compared with cases with invasion. Cases without desmoplasia in the positive lymph nodes had significantly longer survival than cases with desmoplasia. The number of positive lymph nodes, desmoplasia in the lymph nodes, and invasion into perinodal fat are the most important prognostic factors in stage IIIc endometrial carcinoma.

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