Obtaining fast dissolving disintegrating tablets with different doses of melatonin

    loading  Checking for direct PDF access through Ovid


Graphical abstractFast dissolving disintegrating tablets (FDDTs) containing different dosages of melatonin have been manufactured for administration to a specific target population: pediatric patients, having potential difficulties taking other oral forms. The lower dosages (3 and 5 mg) are intended for epileptic children, migraine prevention, neurodevelopmental disability, sleep disorders and blindness. Dosages of 10 and 60 mg are intended for Duchenne muscular dystrophy. Two FDDT groups have been designed, one which has excipients for direct compression and others having direct compression and effervescent excipients. Tablets have been produced having disintegration times of less than 25 s and with friability and hardness values that require no special storage or packaging conditions.

    loading  Loading Related Articles